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Real progress appears in shrinking body measurements, lower body fat percentage, increasing strength metrics such as more push-ups or longer plank holds, faster mile times, and improved bloodwork

The confirmatory secondary endpoints included the change in the 6-min walking distance, a hierarchical composite of death and heart failure events

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Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo